After entering the body, pathogenic bacteria move to the regional lymph nodes. There they multiply and then enter the bloodstream, releasing toxins and leading to the first signs of the disease. However, bacteria often persist in some organs and tissues where they escape the harmful effects of the host's immune system. This leads to a chronic disease. Also, with a long course of the disease, sensitivity to foreign agents increases, primarily due to the development of allergic reactions to the brucellosis antigen. This radically changes the course of the immune process - against this background, repeated (multiple) generalization occurs, in which Brucella leave the metastatic foci, enter the blood again, leading to the development of a relapse. Classification and stages of development of brucellosis.
The International Classification of Diseases (ICD-10) classifies brucellosis depending on the type of pathogenic bacterium: The infectious disease doctor G.P. Rudnev in 1966 identified five forms of chronic brucellosis, based on the clinical picture of the disease: Epidemiologist and infectious disease specialist V. I. Pokrovsky singled out four forms of the course of the disease: Clinical forms of brucellosis:
Differential diagnosis: Regardless of the form, treatment is carried out in the infectious diseases department of the hospital or the ICU (intensive care unit). Mode - ward, bed or semi-bed. The diet No. 2 or No. 7 according to Pevzner is shown (restriction of the intake of sodium ions with control of the level of incoming fluid).