With a long course of brucellosis, muscle pains appear (most severely in the limbs and lower back) and fibrositis - longitudinal painful seals under the skin. With inflammation of the sacroiliac joints, a number of characteristic pain phenomena occur, which are paid attention to during diagnosis: In some cases, men develop pain and swelling in the scrotum and testicles (orchitis), women experience salpingo-oophoritis - inflammation of the fallopian tubes and ovaries. There is also a residual form, or persistent residual effects of brucellosis. They develop if the disease lasts more than 2 years.
The transition of the chronic form to the residual one is characterized by the fact that fresh foci of infection and intoxication no longer occur. This indicates that the causative agent of brucellosis is absent in the human body. Residual effects are mainly associated with immunoallergic restructuring of the body and disorders of the autonomic nervous system. There is sweating, irritability, neuropsychic symptoms, arthralgia, body temperature sometimes rises to 37.1–38.0 °C.