Treatment aimed at the cause of brucellosis is most effective in the acute period, that is, in the first three days of the disease (short courses). With a long course of the disease (subacute and chronic forms), the course of therapy should be at least six weeks.
Before starting therapy, it is necessary to introduce a standard therapeutic dose of prednisolone in order to avoid the development of an allergic Jarisch-Herxheimer reaction (occurs due to the massive death of bacteria and the release of a large amount of their antigens). Tetracycline group drugs, aminoglycosides, sulfonamides are used. A specific scheme is prescribed by a doctor (preferably with experience in the treatment of brucellosis) based on the form of the disease, the previous treatment. Taking into account the initial toxicity of drugs and the multiple side effects of their combinations, it is recommended to conduct treatment in a hospital under the supervision and cover of anti-inflammatory drugs.allergic agents.
From the arsenal of pathogenetic therapy that suppresses the mechanisms of development of brucellosis, intravenous infusion of glucose-salt solutions, 5% glucose is widely used. Colloidal solutions are contraindicated. In case of heart failure, cardiac glycosides are used, in arterial hypertension - dopamine, in case of kidney dysfunction - diuretics, hyperbaric oxygenation (oxygen treatment in a pressure chamber), enterosorbents can be used in short courses. In severe forms, plasmapheresis and hemosorption (methods of blood purification) are indicated.
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Discharge of patients is carried out with a stable normalization of body temperature, the absence of clinical symptoms and the normalization of basic laboratory tests.
Brucellosis is a disease characterized by damage to the musculoskeletal system, nervous, reproductive and other systems. Brucella are stable in the external environment. They remain in water for more than 2 months, in milk - 40 days, in cheese - 2 months, in raw meat - 3 months, in salted meat - up to 30 days, in wool - up to 4 months. Brucella die when heated and under the influence of many disinfectants.
With timely treatment and the absence of complications, especially acute renal failure and hemorrhagic syndrome, the prognosis is relatively favorable. With the development of these complications, a long-term neglected course of the disease, disability and death are possible.